Anti-tumor Activity of Indole Derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis and Anti-inflammatory Activity of Indole Derivatives
The present investigation is concerned with synthesis of new substituted indole derivatives 1-39 with the objective of discovering novel and potent anti-inflammatory agent. The structure of all the synthesized compounds were elucidated by spectral (IR, HNMR and mass) and elemental (C, H, N) analysis. The obtained compounds were screened for their anti-inflammatory as well as analgesic activitie...
متن کامل[Synthesis and anti-tumor activity of oleanolic acid derivatives].
Thirteen novel oleanolic acid (OA) derivatives were designed and synthesized with modification at positions of C-3, C-12 and C-28 of OA. Their structures were confirmed by MS, 1H NMR and elemental analysis. Their in vitro cytotoxicities against various cancer cell lines (SGC7901, MCF-7 and A549) were evaluated by MTT assay. The results indicated that the tested derivatives were found to have st...
متن کاملSynthesis, Antiplatelet Activity and Cytotoxicity Assessment of Indole-Based Hydrazone Derivatives
A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...
متن کاملSynthesis, Antiplatelet Activity and Cytotoxicity Assessment of Indole-Based Hydrazone Derivatives
A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...
متن کاملanti-toxoplasma activity of 2-(naphthalene-2-γlthiol)-1h indole.
background: this study was undertaken to evaluate the viability, infectivity and immunity of toxoplasma gondii tachyzoites exposed to 2-(naphthalene-2-ylthio)-1h-indole. methods : tachyzoites of rh strain were incubated in various concentrations of 2- (naphthalene-2-ylthio)-1h-indole (25-800μm) for 1.5 hours. then, they were stained by pi and analyzed by fluorescence-activated cell sorting (f...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1977
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.97.9_1033